MRPL1

Also known as BM022, L1MT, MRP-L1, mitochondrial ribosomal protein L1

protein-coding gene in the species Homo sapiens

Gene data

MRPL1

Name: mitochondrial ribosomal protein L1
Type: protein-coding
Position: 77,862,139–77,952,791 (+)
Aliases: BM022, L1MT, MRP-L1, uL1m
Ensembl: ENSG00000169288
RefSeq RNA: NM_020236.4, XM_047416089.1, XM_047416090.1, XM_054350733.1, XM_054350734.1
RefSeq protein: NP_064621.3, XP_047272045.1, XP_047272046.1, XP_054206708.1, XP_054206709.1

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. [provided by RefSeq, Jul 2008].