EIF5B
Sign in to saveAlso known as IF2, eukaryotic translation initiation factor 5B
Eukaryotic translation initiation factor 5B is a protein that in humans is encoded by the EIF5B gene. eIF5B is homologous to the bacterial initiation factor 2, sharing a core structure while their involvement in translation initiation differs.
Gene data
EIF5B- Name
- eukaryotic translation initiation factor 5B
- Type
- protein-coding
- Aliases
- IF2
Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
eukaryotic translation initiation factor 5B
- Symbol
- EIF5B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:99,337,361-99,401,326
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 134613
- exact match
- identifiers.org/ncbigene/9669
- genomic end
- 100017789
- genomic start
- 99337371
- cytogenetic location
- 2q11.2
Sources (4)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Function
- References
- Further reading
Eukaryotic translation initiation factor 5B is a protein that in humans is encoded by the EIF5B gene. eIF5B is homologous to the bacterial initiation factor 2, sharing a core structure while their involvement in translation initiation differs.
== Function ==