PCBP1
Sign in to saveAlso known as HEL-S-85, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X, poly(rC) binding protein 1
Poly(rC)-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene.
Gene data
PCBP1- Name
- poly(rC) binding protein 1
- Type
- protein-coding
- Aliases
- HEL-S-85, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
poly(rC) binding protein 1
- Symbol
- PCBP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:70,087,477-70,089,203
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein PCBP1 PDB 1wvn.png
Show 5 more facts
- HomoloGene ID
- 68506
- exact match
- identifiers.org/ncbigene/5093
- genomic end
- 70316332
- genomic start
- 70087477
- cytogenetic location
- 2p13.3
Sources (3)
via Wikidata · CC0
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Article
2 sectionsContents
- References
- Further reading
Poly(rC)-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene.
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP2 and HNRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure.