renin
Sign in to saveAlso known as angiotensinogenase, angiotensin-forming enzyme, REN, renin precursor, renal
Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin–angiotensin–aldosterone system (RAAS), which increases the volume of extracellular fluid (blood plasma, lymph, and interstitial fluid) and causes arterial vasoconstriction. Thus, it increases the body's mean arterial blood pressure.
Key facts
- Enzyme.Name
- renin
- Enzyme.EC_number
- 3.4.23.15
- Enzyme.CAS_number
- 9015-94-5
- Enzyme.GO_code
- 0004195
via Wikipedia infobox
Protein · UniProt
Renin
- Gene
- REN
- Organism
- Homo sapiens (Human)
- Length
- 406 aa
- Molecular mass
- 45,057 Da
- Evidence
- 1: Evidence at protein level
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney
Swiss-Prot (reviewed) · via UniProt
Research
74,197 papers- (Pro)renin receptor as a therapeutic target for the treatment of cardiovascular diseases?Pharmacological research · 2017
- Functional testing: renin studies.Seminars in nephrology · 2000
- [Renin-angiotensin system].Nihon rinsho. Japanese journal of clinical medicine · 1992
- The molecular biology of human renin and its gene.The Yale journal of biology and medicine · 1989
- Fifty years of research on the brain renin-angiotensin system: what have we learned?Clinical science (London, England : 1979) · 2021
via PubMed
Clinical Trials
299 registered- PHASE4UNKNOWNAliskiren and Muscle Sympathetic Nerve ActivityUMC Utrecht · NCT00719316
- COMPLETEDMechanisms and Phenotypes of Hypertension in Patients in Chronic HemodialysisBernardo Rodríguez Iturbe · NCT06764277
- PHASE1/PHASE2UNKNOWNEffects of an Immunosuppressant Mycophenolate Mofetil or MMF on the Urinary Sodium Excretion Response to Mental StressAugusta University · NCT02432339
- COMPLETEDEffect of Renin-Angiotensin System on Platelet in Patient With SepsisXinhua Hospital, Shanghai Jiao Tong University School of Medicine · NCT03952390
- PHASE4UNKNOWNRenin-angiotensin System Blockade Benefits in Clinical Evolution and Ventricular Remodeling After Transcatheter Aortic Valve Implantation (RASTAVI)Hospital Clínico Universitario de Valladolid · NCT03201185
- NANOT_YET_RECRUITINGRAndomized EHR-based Prescribing to Improve Disease-modifying Therapies for Cardio-Kidney-Metabolic Care (RAPID-CKM)Baylor Research Institute · NCT07605390
Wikidata facts
Show 2 more facts
- Commons category
- Renin
- exact match
- purl.uniprot.org/uniprot/P00797
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~8 min read
Article
13 sectionsContents
- Biochemistry and physiology
- Structure
- Secretion
- Renin–angiotensin system
- Function
- Genetics
- Clinical applications
- Measurement
- Discovery and naming
- See also
- References
- Further reading
- External links
Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin–angiotensin–aldosterone system (RAAS), which increases the volume of extracellular fluid (blood plasma, lymph, and interstitial fluid) and causes arterial vasoconstriction. Thus, it increases the body's mean arterial blood pressure.
Renin is not commonly referred to as a hormone, although it has a receptor, the (pro)renin receptor, also known as the renin receptor and prorenin receptor (see also below), as well as enzymatic activity with which it hydrolyzes angiotensinogen to angiotensin I.