renin
Also known as angiotensinogenase, angiotensin-forming enzyme, REN, renin precursor, renal
Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin–angiotensin–aldosterone system (RAAS), which increases the volume of extracellular fluid (blood plasma, lymph, and interstitial fluid) and causes arterial vasoconstriction. Thus, it increases the body's mean arterial blood pressure.
Key facts
- Enzyme.Name
- renin
- Enzyme.EC_number
- 3.4.23.15
- Enzyme.CAS_number
- 9015-94-5
- Enzyme.GO_code
- 0004195
via Wikipedia infobox
Research
74,197 papers- (Pro)renin receptor as a therapeutic target for the treatment of cardiovascular diseases?Pharmacological research · 2017
- Functional testing: renin studies.Seminars in nephrology · 2000
- [Renin-angiotensin system].Nihon rinsho. Japanese journal of clinical medicine · 1992
- The molecular biology of human renin and its gene.The Yale journal of biology and medicine · 1989
- Fifty years of research on the brain renin-angiotensin system: what have we learned?
Article
13 sectionsContents
- Biochemistry and physiology
- Structure
- Secretion
- Renin–angiotensin system
- Function
- Genetics
- Clinical applications
- Measurement
- Discovery and naming
- See also
- References
- Further reading
- External links
Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin–angiotensin–aldosterone system (RAAS), which increases the volume of extracellular fluid (blood plasma, lymph, and interstitial fluid) and causes arterial vasoconstriction. Thus, it increases the body's mean arterial blood pressure.
Renin is not commonly referred to as a hormone, although it has a receptor, the (pro)renin receptor, also known as the renin receptor and prorenin receptor (see also below), as well as enzymatic activity with which it hydrolyzes angiotensinogen to angiotensin I.