Plectin
Sign in to saveAlso known as Plectin-1, hemidesmosomal protein 1, PLEC, plectin 1, intermediate filament binding protein 500kDa, HD1
Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. In addition, plectin links the cytoskeleton to junctions found in the plasma membrane that structurally connect different cells. By holding these different networks together, plectin plays an important role in maintaining the mechanical integrity and viscoelastic properties of tissues.
Protein · UniProt
Plectin
- Gene
- PLEC
- Organism
- Homo sapiens (Human)
- Length
- 4,684 aa
- Molecular mass
- 531,791 Da
- Evidence
- 1: Evidence at protein level
Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
3 registered- RECRUITINGCongenital Muscle Disease Study of Patient and Family Reported Medical InformationCure CMD · NCT01403402
- PHASE1/PHASE2COMPLETEDA Phase 1/2, First-in-Human, Open Label, Dose Escalation Study Of A CSP Targeting Functional Antibody in Solid TumorsZielBio, Inc. · NCT05074472
- NOT_YET_RECRUITINGCell-Surface Plectin in the Diagnosis of Cholangiocarcinoma from ERCP-directed Biliary SamplesUniversity of Virginia · NCT06651346
~4 min read
Article
7 sectionsContents
- Structure
- Function
- Clinical significance
- See also
- References
- Further reading
- External links
Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. In addition, plectin links the cytoskeleton to junctions found in the plasma membrane that structurally connect different cells. By holding these different networks together, plectin plays an important role in maintaining the mechanical integrity and viscoelastic properties of tissues.
== Structure ==