Fibronectin 1
Sign in to saveAlso known as epididymis secretory sperm binding protein, FN1, CIG, fibronectin, cold-insoluble globulin, migration-stimulating factor, Fibronectin
thumb|right|400px|The modular structure of fibronectin and its binding domains Fibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans).
Protein · UniProt
Fibronectin
- Gene
- FN1
- Organism
- Homo sapiens (Human)
- Length
- 2,477 aa
- Molecular mass
- 272,320 Da
- Evidence
- 1: Evidence at protein level
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3593230, PubMed:3900070, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed:3024962, PubMed:3593230, PubMed:3900070, PubMed:7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteobl…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
22 registered- UNKNOWNfFN Clinical Evaluation in Asymptomatic Women at High Risk for Preterm BirthHologic, Inc. · NCT01955148
- COMPLETEDPredictability of Gestational Diabetes Mellitus in First and Second TrimesterUniversity Hospital, Basel, Switzerland · NCT02035059
- COMPLETEDComparison of Fetal Fibronectin (fFN) Specimen Collection Methodologies: With Speculum Versus Without SpeculumHologic, Inc. · NCT00883324
- NACOMPLETEDTwo Methods of Diagnosing Preterm LaborUniversity of California, San Francisco · NCT01431885
- TERMINATEDThe Use of Fetal Fibronectin to Predict Delivery Due to Abruptio PlacentaWinthrop University Hospital · NCT01279369
- PHASE4TERMINATEDImmunohistochemical Study of Human Teeth Pulp Capped With Mineral Trioxide Aggregate (MTA) and Novel Endodontic Cement (NEC)Mashhad University of Medical Sciences · NCT01066533
Wikidata facts
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- exact match
- purl.uniprot.org/uniprot/P02751
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- Fibronectin
via Wikidata · CC0
~12 min read
Article
11 sectionsContents
- Structure
- Function
- Matrix assembly
- Role in cancer
- Role in wound healing
- Fibronectin genetic variation as a protective factor against Alzheimer's disease
- Interactions
- See also
- References
- Further reading
- External links
thumb|right|400px|The modular structure of fibronectin and its binding domains Fibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans).
Fibronectin exists as a protein dimer, consisting of two nearly identical monomers linked by a pair of disulfide bonds. The fibronectin protein is produced from a single gene, but alternative splicing of its pre-mRNA leads to the creation of several isoforms.