elastin
Sign in to saveAlso known as tropoelastin, ELN
thumb|200x200px|Thick elastic fibers consisting of bundles of elastin in the human lung Elastin is a protein encoded by the ELN gene in humans and several other animals. Elastin is a key component in the extracellular matrix of gnathostomes (jawed vertebrates). It is highly elastic and present in connective tissue of the body to resume its shape after stretching or contracting. Elastin helps skin return to its original position whence poked or pinched. Elastin is also in important load-bearing tissue of vertebrates and used in places where storage of mechanical energy is required.
Protein · UniProt
Elastin
- Gene
- ELN
- Organism
- Homo sapiens (Human)
- Length
- 786 aa
- Molecular mass
- 68,398 Da
- Evidence
- 1: Evidence at protein level
Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity)
Swiss-Prot (reviewed) · via UniProt
Research
17,659 papers- Elastin.Advances in protein chemistry · 2005
- Elastin Biomaterials in Dermal Repair.Trends in biotechnology · 2020
- Elastin in the Tumor Microenvironment.Advances in experimental medicine and biology · 2020
- Elastin in healthy and diseased lung.Current opinion in biotechnology · 2022
- Fabricated Elastin.Advanced healthcare materials · 2015
via PubMed
Clinical Trials
20 registered- NACOMPLETEDEffects of Emotion on Episodic Memory in Typically Developing Children and Children With Williams-Beuren SyndromeHôpital le Vinatier · NCT03688516
- NACOMPLETEDThe Effects of Microdermabrasion on Skin RemodelingUniversity of Michigan · NCT00111254
- PHASE1/PHASE2ACTIVE_NOT_RECRUITINGA Study Assessing KB304 for the Treatment of Wrinkles in WomenKrystal Biotech, Inc. · NCT06724900
- UNKNOWNThe Effects of Discontinuation of Vitamin K Antagonists on the Rate of Elastin DegradationCanisius-Wilhelmina Hospital · NCT03285100
- RECRUITINGCharacterization and Natural History of Williams Syndrome and Other Chromosome 7q11.23 VariantsUniversity of Pennsylvania · NCT06930417
- NACOMPLETEDEfficacy of Collagen-elastin Dermal Substitute in the Treatment of Loss of Cutaneous Substances With Skin GraftsUniversity Hospital, Rouen · NCT02090361
~7 min read
Article
17 sectionsContents
- Function
- Mechanism of elastic recoil
- Clinical significance
- Elastosis
- Composition
- Tissue distribution
- Characteristics
- Clinical research
- Biosynthesis
- Tropoelastin precursors
- Aggregation
- Crosslinking
- Molecular biology
- See also
- References
- Further reading
- External links
thumb|200x200px|Thick elastic fibers consisting of bundles of elastin in the human lung Elastin is a protein encoded by the ELN gene in humans and several other animals. Elastin is a key component in the extracellular matrix of gnathostomes (jawed vertebrates). It is highly elastic and present in connective tissue of the body to resume its shape after stretching or contracting. Elastin helps skin return to its original position whence poked or pinched. Elastin is also in important load-bearing tissue of vertebrates and used in places where storage of mechanical energy is required.
== Function ==