collagen

Also known as GO:0005581, collogen

thumb|upright=1.5|The triple helix: three left-handed polyproline type II helices (red, green, blue) assemble by an axial hydrogen bond to form a right-handed triple helix, the tertiary structure of collagen.

AI overview

Collagen is a protein made up of three intertwined strands that form a stable triple-helix structure, which gives it strength and stability. This structural arrangement is important because it allows collagen to provide support and firmness to tissues throughout the body.

AI-generated from the Wikipedia summary — may contain errors.

Research

297,411 papers

Type 1 collagen: Synthesis, structure and key functions in bone mineralization.ReviewDifferentiation; research in biological diversity · 2024Selvaraj V, Sekaran S, Dhanasekaran A et al.DOI: 10.1016/j.diff.2024.100757
The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development.ReviewAdvanced materials (Deerfield Beach, Fla.) · 2019Sorushanova A, Delgado LM, Wu Z et al.DOI: 10.1002/adma.201801651
Mechanochemistry of collagen.ReviewActa biomaterialia · 2023Siadat SM, Ruberti JWDOI: 10.1016/j.actbio.2023.01.025
Role of Collagen Regulators in Cancer Treatment: A Comprehensive Review.ReviewAnti-cancer agents in medicinal chemistry · 2022Angre T, Kumar A, Singh AK et al.DOI: 10.2174/1871520622666220501162351
Mechanobiology of Collagen Synthesis, Assembly, and Mineralization.ReviewJournal of dental research · 2025Wang S, Song F, Liang S et al.DOI: 10.1177/00220345251361795
Hydrated Collagen: Where Physical Chemistry, Medical Imaging, and Bioengineering Meet.ReviewThe journal of physical chemistry. B · 2022Momot KIDOI: 10.1021/acs.jpcb.2c06217
Collagen Mechanics.Sub-cellular biochemistry · 2026Szarek P, Ruberti JWDOI: 10.1007/978-3-032-05273-5_10
The Multifaced Role of Collagen in Cancer Development and Progression.ReviewInternational journal of molecular sciences · 2024Lo Buglio G, Lo Cicero A, Campora S et al.DOI: 10.3390/ijms252413523

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Wikidata facts

Image: Fibers of Collagen Type I - TEM .jpg

Show 3 more facts

Commons gallery: Collagen
Commons category: Collagen
exact match: purl.obolibrary.org/obo/GO_0005581

Sources (2)

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~34 min read

Article

24 sections

Contents

Etymology
Types
In humans
Cardiac
Bone grafts
Tissue regeneration
Reconstructive surgery
Wound healing
Use in basic research
Biology
Synthesis
Amino acids
Collagen I formation
Molecular structure
Associated disorders
Diseases
Animal harvesting
Characteristics
Mechanical properties
Uses
Cosmetics
History
See also
References

Collagen () is the main structural protein in the extracellular matrix of the connective tissues of many animals. It is the most abundant protein in mammals, making up 25% to 35% of protein content. Amino acids are bound together to form a triple helix of elongated fibril known as a collagen helix. It is mostly found in cartilage, bones, tendons, ligaments, and skin. Vitamin C is vital for collagen synthesis.