P4HA2
Sign in to saveAlso known as prolyl 4-hydroxylase subunit alpha 2, MYP25, lncRNA-PE
Prolyl 4-hydroxylase subunit alpha-2 is an enzyme that in humans is encoded by the P4HA2 gene.
In the Vinony graph
Vinony's link graph records 2 inbound references to P4HA2, and connects out to PubMed, collagen and human chromosome 5.
It is catalogued under the topic Genes on human chromosome 5.
Vinony links it to 5 Wikipedia language editions.
Gene data
P4HA2- Name
- prolyl 4-hydroxylase subunit alpha 2
- Type
- protein-coding
- Position
- 132,190,094–132,295,315 (−)
- Aliases
- MYP25, lncRNA-PE
- Ensembl
- ENSG00000072682
- RefSeq RNA
- NM_001017974.2, NM_001142598.2, NM_001142599.2, NM_001365677.2, NM_001365678.2
- RefSeq protein
- NP_001017974.1, NP_001136070.1, NP_001136071.1, NP_001352606.1, NP_001352607.1
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
prolyl 4-hydroxylase subunit alpha 2
- Symbol
- P4HA2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:132,190,094-132,295,315
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 55806
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8974
- genomic end
- 131631008
- genomic start
- 132190147
- chromosome
- human chromosome 5
- cytogenetic location
- 5q31.1
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Prolyl 4-hydroxylase subunit alpha-2 is an enzyme that in humans is encoded by the P4HA2 gene.
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.
Excerpted from Wikipedia’s “P4HA2” article, available under the CC BY-SA 4.0 licence.