vitronectin
Sign in to saveAlso known as serum spreading factor, V75, epibolin, S-protein, VTN, complement S-protein, Serum-spreading factor
Vitronectin (VTN or VN) is a glycoprotein of the hemopexin family which is synthesized and excreted by the liver, and abundantly found in serum, the extracellular matrix and bone. In humans it is encoded by the VTN gene.
Protein · UniProt
Vitronectin
- Gene
- VTN
- Organism
- Homo sapiens (Human)
- Length
- 478 aa
- Molecular mass
- 54,306 Da
- Evidence
- 1: Evidence at protein level
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway
Swiss-Prot (reviewed) · via UniProt
Research
6,206 papers- Vitronectin.The international journal of biochemistry & cell biology · 1999
- Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier.Neuron · 2022
- Vitronectin and its receptors.Current opinion in cell biology · 1993
- Vitronectin in atherosclerotic disease.Clinica chimica acta; international journal of clinical chemistry · 2006
- Vitronectin--master controller or micromanager?IUBMB life · 2013
via PubMed
Clinical Trials
22 registered- PHASE3UNKNOWNAn Observer-blind, Cohort Randomized, Exploratory Phase 3 Study to Evaluate the Safety and Immunogenicity of Recombinant Covid-19 Vaccine, mRNA Covid-19 Vaccine and Recombinant SARS-CoV-2 Trimeric S-protein Subunit Vaccine as 4th Dose in Individuals Primed/ Boosted With Various RegimensD'Or Institute for Research and Education · NCT05470803
- PHASE2UNKNOWNImmunogenicity and Safety Study of Adjuvanted SARS-CoV-2 (SCB-2019) Vaccine in Adultsin ChinaZhejiang Clover Biopharmaceuticals, Inc. · NCT04954131
- PHASE1COMPLETEDSafety and Immunogenicity Dose-finding Study of Adjuvanted SCB-2020S Vaccine in AdultsClover Biopharmaceuticals AUS Pty · NCT05228314
- PHASE2UNKNOWNEfficacy and Safety of JS016 in Patients With SARS-CoV-2 Infection (COVID-19)Peking Union Medical College Hospital · NCT04931238
- PHASE1COMPLETEDLong-term Follow-up to the Phase 1 Study of Adjuvanted SARS-CoV-2 (SCB 2019) Vaccine for COVID-19.Clover Biopharmaceuticals AUS Pty · NCT04932824
- PHASE1TERMINATEDCORVax12: SARS-CoV-2 Spike (S) Protein Plasmid DNA Vaccine Trial for COVID-19 (SARS-CoV-2)Providence Health & Services · NCT04627675
~3 min read
Article
5 sectionsContents
- Structure
- Function
- References
- Further reading
- External links
Vitronectin (VTN or VN) is a glycoprotein of the hemopexin family which is synthesized and excreted by the liver, and abundantly found in serum, the extracellular matrix and bone. In humans it is encoded by the VTN gene.
Vitronectin binds to integrin alpha-V beta-3 and thus promotes cell adhesion and spreading. It also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpins (serine protease inhibitors). It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. Vitronectin has been speculated to be involved in hemostasis and tumor malignancy.