TECTA

Also known as DFNA12, DFNA8, DFNB21, tectorin alpha

Alpha-tectorin is a protein that in humans is encoded by the TECTA gene.

Gene data

TECTA

Name: tectorin alpha
Type: protein-coding
Position: 121,101,243–121,191,490 (+)
Aliases: DFNA12, DFNA8, DFNB21
Ensembl: ENSG00000109927
RefSeq RNA: NM_005422.4
RefSeq protein: NP_005413.2

The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

cell-matrix adhesion sensory perception of sound sensory perception of sound

Molecular function

extracellular matrix structural constituent extracellular matrix structural constituent

Cellular component

extracellular region plasma membrane plasma membrane extracellular matrix extracellular matrix extracellular exosome cell periphery

Pathways

Post-translational modification: synthesis of GPI-anchored proteins Metabolism of proteins Post-translational protein modification

via MyGene.info

Gene · Ensembl

tectorin alpha

Symbol: TECTA
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:121,101,243-121,191,490
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 3955
exact match: identifiers.org/ncbigene/7007
genomic end: 121191490
genomic start: 121101243
cytogenetic location: 11q23.3

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Alpha-tectorin is a protein that in humans is encoded by the TECTA gene.

The tectorial membrane is an apical extracellular matrix (aECM) of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness.