TECTA

Also known as DFNA12, DFNA8, DFNB21, tectorin alpha

Alpha-tectorin is a protein that in humans is encoded by the TECTA gene.

Gene data

TECTA

Name: tectorin alpha
Type: protein-coding
Position: 121,101,243–121,191,490 (+)
Aliases: DFNA12, DFNA8, DFNB21
Ensembl: ENSG00000109927
RefSeq RNA: NM_005422.4
RefSeq protein: NP_005413.2

The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

cell-matrix adhesion

Article

2 sections

Contents

References
Further reading

Alpha-tectorin is a protein that in humans is encoded by the TECTA gene.

The tectorial membrane is an apical extracellular matrix (aECM) of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness.