FREM2

Also known as FRAS1 related extracellular matrix protein 2, FRASRS2, FRAS1 related extracellular matrix 2, CRYPTOP

FRAS1-related extracellular matrix protein 2 is a protein that in humans is encoded by the FREM2 gene.

Gene data

FREM2

Name: FRAS1 related extracellular matrix 2
Type: protein-coding
Aliases: CRYPTOP, FRASRS2

This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome. [provided by RefSeq, Apr 2014].

via MyGene.info

Gene · Ensembl

FRAS1 related extracellular matrix 2

Symbol: FREM2
Biotype: Protein coding
Organism: Homo sapiens
Location: 13:38,687,070-38,887,131
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 18454
exact match: identifiers.org/ncbigene/341640
genomic start: 38687077
genomic end: 39460074
cytogenetic location: 13q13.3

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FRAS1-related extracellular matrix protein 2 is a protein that in humans is encoded by the FREM2 gene.

This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser syndrome.