Vitronectina
Sign in to saveAlso known as Vitronectin, serum spreading factor, V75, epibolin, S-protein, VTN, complement S-protein, Serum-spreading factor
proteína de Homo sapiens
In the Vinony graph
Within Vinony's link graph, Vitronectina is referenced by 211 other articles, and connects out to mucin, PubMed and elastin.
It is catalogued under topics including Cell adhesion proteins, Extracellular matrix proteins and Genes on human chromosome 17.
Its subject is documented across 13 Wikipedia language editions.
Protein · UniProt
Vitronectin
- Gene
- VTN
- Organism
- Homo sapiens (Human)
- Length
- 478 aa
- Molecular mass
- 54,306 Da
- Evidence
- 1: Evidence at protein level
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway
Swiss-Prot (reviewed) · via UniProt
Research
6,206 papers- Vitronectin.The international journal of biochemistry & cell biology · 1999
- Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier.Neuron · 2022
- Vitronectin and its receptors.Current opinion in cell biology · 1993
- Vitronectin in atherosclerotic disease.Clinica chimica acta; international journal of clinical chemistry · 2006
- Vitronectin--master controller or micromanager?IUBMB life · 2013
via PubMed
Clinical Trials
22 registered- PHASE3UNKNOWNAn Observer-blind, Cohort Randomized, Exploratory Phase 3 Study to Evaluate the Safety and Immunogenicity of Recombinant Covid-19 Vaccine, mRNA Covid-19 Vaccine and Recombinant SARS-CoV-2 Trimeric S-protein Subunit Vaccine as 4th Dose in Individuals Primed/ Boosted With Various RegimensD'Or Institute for Research and Education · NCT05470803
- PHASE2UNKNOWNImmunogenicity and Safety Study of Adjuvanted SARS-CoV-2 (SCB-2019) Vaccine in Adultsin ChinaZhejiang Clover Biopharmaceuticals, Inc. · NCT04954131
- PHASE1COMPLETEDSafety and Immunogenicity Dose-finding Study of Adjuvanted SCB-2020S Vaccine in AdultsClover Biopharmaceuticals AUS Pty · NCT05228314
- PHASE2UNKNOWNEfficacy and Safety of JS016 in Patients With SARS-CoV-2 Infection (COVID-19)Peking Union Medical College Hospital · NCT04931238
- PHASE1COMPLETEDLong-term Follow-up to the Phase 1 Study of Adjuvanted SARS-CoV-2 (SCB 2019) Vaccine for COVID-19.Clover Biopharmaceuticals AUS Pty · NCT04932824
- PHASE1TERMINATEDCORVax12: SARS-CoV-2 Spike (S) Protein Plasmid DNA Vaccine Trial for COVID-19 (SARS-CoV-2)Providence Health & Services · NCT04627675
Wikidata facts
- Instance of
- protein
Show 2 more facts
- biological process
- endocytosis
- found in taxon
- Homo sapiens
via Wikidata · CC0
Article · Español
La vitronectina (VTN o VN) es una glucoproteína de la familia de la hemopexina que se encuentra abundantemente en el suero, la matriz extracelular y el hueso. En los humanos está codificado por el gen VTN. La vitronectina se une a la integrina alfa-V beta-3 (αVβ3), promoviendo la adhesión y la diseminación celular. También inhibe el efecto dañino sobre la membrana de la ruta del complemento citolítico, y se une a varias serpinas (inhibidores de serina proteasa). Es una proteína secretada y existe en forma de cadena única o en forma acoplada, con dos cadenas recortadas unidas por un enlace disulfuro. Se ha especulado que la vitronectina está implicada en la hemostasia y en la malignidad tumoral.
Abstract from DBpedia / Wikipedia · CC BY-SA