File:Losartan_structure.svg · Wikimedia Commons · See Wikimedia Commons
losartan
Sign in to saveAlso known as DuP 753, MK-954, 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole, (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol, DuP 89
Losartan, sold under the brand name Cozaar among others, is a medication used to treat high blood pressure (hypertension). It is in the angiotensin receptor blocker (ARB) family of medication, and is considered protective of the kidneys. Besides hypertension, it is also used in diabetic kidney disease, heart failure, and left ventricular enlargement. It comes as a tablet that is taken by mouth. It may be used alone or in addition to other blood pressure medication. Up to six weeks may be required for the full effects to occur.
Key facts
- Drug.verifiedrevid
- 458612349
- Drug.image
- Losartan structure.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Skeletal formula
- Drug.width
- 200
- Drug.image2
- Losartan-from-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Ball-and-stick model
- Drug.tradename
- Cozaar, others
- Drug.MedlinePlus
- a695008
- Drug.DailyMedID
- Losartan
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- By mouth
- Drug.class
- Angiotensin II receptor antagonist
- Drug.ATC_prefix
- C09
- Drug.ATC_suffix
- CA01
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C22H23ClN6O
- Molecular weight
- 422.9 g/mol
- IUPAC name
- [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
- SMILES
- CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
- InChIKey
- PSIFNNKUMBGKDQ-UHFFFAOYSA-N
- XLogP
- 4.3
- Polar surface area
- 92.5 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
11,351 papers- Clinical pharmacokinetics of losartan.Clinical pharmacokinetics · 2005
- Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
- Hyperuricemia and Gout: The Role of Losartan.The Senior care pharmacist · 2023
- Topical Losartan in the Management of Corneal Scarring Fibrosis: Update on Dosage, Efficacy, and Potential Epithelial Toxicity.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2025
- Topical Losartan in the Treatment of Stromal Scarring After Refractive Surgery.Journal of refractive surgery (Thorofare, N.J. : 1995) · 2025
via PubMed
Wikidata facts
- Mass
- 422.162
Show 5 more facts
- chemical formula
- C₂₂H₂₃ClN₆O
- Commons category
- Losartan
- canonical SMILES
- CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
- defined daily dose
- 50
- World Health Organisation international non-proprietary name
- losartan
Sources (6)
via Wikidata · CC0
~11 min read
Article
13 sectionsContents
- Chemistry
- Medical uses
- Adverse effects
- Pregnancy
- Overdose
- Interactions
- Contamination
- Mechanism of action
- Pharmacokinetics
- History
- References
- Further reading
- External links
{{Infobox drug | verifiedrevid = 458612349 | image = Losartan structure.svg | image_class = skin-invert-image | alt = Skeletal formula | width = 200 | image2 = Losartan-from-xtal-3D-bs-17.png | image_class2 = bg-transparent | alt2 = Ball-and-stick model | width2 = | caption =
| pronounce = | tradename = Cozaar, others | Drugs.com = | MedlinePlus = a695008 | DailyMedID = Losartan | pregnancy_AU = D | pregnancy_AU_comment = | pregnancy_category= | routes_of_administration = By mouth | class = Angiotensin II receptor antagonist | ATC_prefix = C09 | ATC_suffix = CA01 | ATC_supplemental =