ARTN

Name

artemin

Type

protein-coding

Position

43,933,272–43,937,244 (+)

Aliases

ART, ENOVIN, EVN, NBN

Ensembl

ENSG00000117407

RefSeq RNA

NM_001136215.2, NM_003976.3, NM_057090.3, NM_057091.3, NM_057160.2

RefSeq protein

NP_001129687.1, NP_476431.2, NP_476432.2, XP_047289613.1, XP_047289621.1

This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. [provided by RefSeq, Aug 2016].

via MyGene.info

Gene · Ensembl

artemin

Symbol

ARTN

Biotype

Protein coding

Organism

Homo sapiens

Location

1:43,933,272-43,937,244

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Artemin Tertiary Structure.png

via Wikidata · CC0