ARTN
Sign in to saveAlso known as ENOVIN, EVN, NBN, artemin, ART
Artemin, also known as enovin or neublastin, is a protein that in humans is encoded by the ARTN gene.
Gene data
ARTN- Name
- artemin
- Type
- protein-coding
- Aliases
- ART, ENOVIN, EVN, NBN
This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. [provided by RefSeq, Aug 2016].
via MyGene.info
Gene · Ensembl
artemin
- Symbol
- ARTN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:43,933,272-43,937,244
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Artemin Tertiary Structure.png
Show 5 more facts
- HomoloGene ID
- 7631
- exact match
- identifiers.org/ncbigene/9048
- genomic end
- 43937240
- genomic start
- 44398992
- cytogenetic location
- 1p34.1
Sources (4)
via Wikidata · CC0
~2 min read
Article
5 sectionsContents
- Function
- Role in axonal development
- References
- Further reading
- External links
Artemin, also known as enovin or neublastin, is a protein that in humans is encoded by the ARTN gene.
== Function ==