CTBP1

Also known as C-terminal binding protein 1, BARS, HADDTS

C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2.

In the Vinony graph

Vinony's link graph records 68 inbound references to CTBP1, and connects out to PubMed, Ensembl genome database project and protein.

It is catalogued under topics including Genes on human chromosome 4 and Transcription coregulators.

Vinony links it to 7 Wikipedia language editions.

Gene data

CTBP1

Name: C-terminal binding protein 1
Type: protein-coding
Position: 1,211,434–1,250,333 (−)
Aliases: BARS, HADDTS
Ensembl: ENSG00000159692
RefSeq RNA: NM_001012614.2, NM_001328.3, NM_001377186.1, NM_001377187.1, NM_001377188.1
RefSeq protein: NP_001012632.1, NP_001319.1, NP_001364115.1, NP_001364116.1, NP_001364117.1

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].

Pathways

Wnt signaling pathway - Homo sapiens (human)Notch signaling pathway - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Chronic myeloid leukemia - Homo sapiens (human)Cell-Cell communication Signal Transduction Disease Degradation of beta-catenin by the destruction complex Signaling by WNT TCF dependent signaling in response to WNT

via MyGene.info

Gene · Ensembl

C-terminal binding protein 1

Symbol: CTBP1
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:1,211,434-1,250,333
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: 6cdf.jpg

Show 8 more facts

HomoloGene ID: 1015
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/1487
genomic end: 1243741
genomic start: 1211445
chromosome: human chromosome 4
cytogenetic location: 4p16.3
expressed in: prefrontal cortex

Sources (4)

via Wikidata · CC0

~3 min read

Encyclopedic overview

5 sections

Contents

Function
Interactions
References
Further reading
External links

C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2.

==Function== The CtBP1 protein was originally identified as a human protein that bound a PLDLS motif in the C-terminus of adenovirus E1A proteins. It and the related protein CTBP2 were later shown to function as transcriptional corepressors. That is, regulatory proteins that bind to sequence-specific DNA-binding proteins and help turn genes off. CtBPs do this by recruiting histone modifying enzymes that add repressive histone marks and remove activating marks. CtBP proteins can also self-associate and presumably bring together gene regulatory complexes.

Excerpted from Wikipedia’s “CTBP1” article, available under the CC BY-SA 4.0 licence.