CTBP1

Also known as C-terminal binding protein 1, BARS, HADDTS

C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2.

Gene data

CTBP1

Name: C-terminal binding protein 1
Type: protein-coding
Position: 1,211,434–1,250,333 (−)
Aliases: BARS, HADDTS
Ensembl: ENSG00000159692
RefSeq RNA: NM_001012614.2, NM_001328.3, NM_001377186.1, NM_001377187.1, NM_001377188.1
RefSeq protein: NP_001012632.1, NP_001319.1, NP_001364115.1, NP_001364116.1, NP_001364117.1

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II

Article

5 sections

Contents

Function
Interactions
References
Further reading
External links

C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2.

==Function== The CtBP1 protein was originally identified as a human protein that bound a PLDLS motif in the C-terminus of adenovirus E1A proteins. It and the related protein CTBP2 were later shown to function as transcriptional corepressors. That is, regulatory proteins that bind to sequence-specific DNA-binding proteins and help turn genes off. CtBPs do this by recruiting histone modifying enzymes that add repressive histone marks and remove activating marks. CtBP proteins can also self-associate and presumably bring together gene regulatory complexes.