ZFPM2
Sign in to saveAlso known as DIH3, FOG2, ZC2HC11B, ZNF89B, hFOG-2, SRXY9, zinc finger protein, FOG family member 2
Zinc finger protein ZFPM2, i.e. zinc finger protein, FOG family member 2, but also termed Friend of GATA2, Friend of GATA-2, FOG2, or FOG-2, is a protein that in humans is encoded by the ZFPM2 and in mice by the Zfpm2 gene.
Gene data
ZFPM2- Name
- zinc finger protein, FOG family member 2
- Type
- protein-coding
- Aliases
- DIH3, FOG2, PRDM19, SRXY9, ZC2HC11B, ZNF89B, hFOG-2
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
zinc finger protein, FOG family member 2
- Symbol
- ZFPM2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:104,590,733-105,805,813
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 8008
- exact match
- identifiers.org/ncbigene/23414
- genomic end
- 105804539
- genomic start
- 106330920
- cytogenetic location
- 8q23.1
Sources (3)
via Wikidata · CC0
~5 min read
Article
9 sectionsContents
- Gene
- Protein
- Pathophysiology
- Clinical relevancy
- Congenital heart disease
- Congenital diaphragmatic hernia
- Sex development
- References
- Further reading
Zinc finger protein ZFPM2, i.e. zinc finger protein, FOG family member 2, but also termed Friend of GATA2, Friend of GATA-2, FOG2, or FOG-2, is a protein that in humans is encoded by the ZFPM2 and in mice by the Zfpm2 gene.
The zinc finger-containing protein encoded by this gene is a widely expressed member of the FOG family of regulators of transcription factors. The family consists of the ZFPM1 and ZFPM2 genes in humans and Zfpm1 and Zfpm2 genes in mice. Its members may act as coactivators and/or corepressors to modulate the activity of GATA transcription factors. That is, the ZFPM2 protein appears able to interact directly with and thereby either enhance or repress the ability of GATA transcription factors to stimulate the expression of their target genes; the direction of ZFPM2's actions depends on the contexts of the promoter sections of the various GATA target genes.