GATA3
Sign in to saveAlso known as HDR, HDRS, GATA binding protein 3
GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that it controls the expression of a wide range of biologically and clinically important genes.
Gene data
GATA3- Name
- GATA binding protein 3
- Type
- protein-coding
- Position
- 8,045,212–8,075,825 (+)
- Aliases
- HDR, HDRS
- Ensembl
- ENSG00000107485
- RefSeq RNA
- NM_001002295.2, NM_001441115.1, NM_001441116.1, NM_001441117.1, NM_001441118.1
- RefSeq protein
- NP_001002295.1, NP_001428044.1, NP_001428045.1, NP_001428046.1, NP_001428047.1
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
GATA binding protein 3
- Symbol
- GATA3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:8,045,212-8,075,825
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- GATA3.png
Show 8 more facts
- HomoloGene ID
- 1550
- genomic start
- 8095567
- genetic association
- hypoparathyroidism-deafness-renal disease syndrome
- chromosome
- human chromosome 10
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2625
- genomic end
- 8075198
- cytogenetic location
- 10p14
Sources (10)
via Wikidata · CC0
~10 min read
Encyclopedic overview
17 sectionsContents
- Gene
- Protein
- Pathophysiology
- Function
- Clinical significance
- Mutations
- Allergy
- Tumors
- Breast tumors
- Development
- Marker
- Other tumor types
- Interactions
- See also
- References
- Further reading
- External links
GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that it controls the expression of a wide range of biologically and clinically important genes.
The GATA3 transcription factor is critical for the embryonic development of various tissues as well as for inflammatory and humoral immune responses and the proper functioning of the endothelium of blood vessels. The GATA factors, GATA1 to GATA6 are a family of zinc finger transcription factors that bind to a consensus DNA sequence (A/T)-G-A-T-A-(A/G) in gene promoters and enhancers. GATA3 plays central role in allergy and immunity against worm infections. GATA3 haploinsufficiency (i.e. loss of one or the two inherited GATA3 genes) results in a congenital disorder termed the Barakat syndrome.
Excerpted from Wikipedia’s “GATA3” article, available under the CC BY-SA 4.0 licence.