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CREB binding protein
Sign in to saveAlso known as RSTS, CREBBP, histone lysine acetyltransferase CREBBP, protein-lysine acetyltransferase CREBBP, CBP, KAT3A, Cyclic AMP Response Element-Binding Protein, CREB-binding protein
mammalian protein found in Homo sapiens
Protein · UniProt
CREB-binding protein
- Gene
- CREBBP
- Organism
- Homo sapiens (Human)
- Length
- 2,442 aa
- Molecular mass
- 265,351 Da
- Evidence
- 1: Evidence at protein level
Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as…
Swiss-Prot (reviewed) · via UniProt
Research
15,056 papers- CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.JCI insight · 2024
- CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer.World journal of gastroenterology · 2015
- CREB-binding protein and p300 in transcriptional regulation.The Journal of biological chemistry · 2001
- Structural and functional characterization of CREB-binding protein (CREBBP) as a histone propionyltransferase.The Journal of biological chemistry · 2025
- CREB-binding protein and p300: molecular integrators of hematopoietic transcription.Blood · 2000
via PubMed
Clinical Trials
7 registered- PHASE2COMPLETEDRubinstein-Taybi Syndrome: Functional Imaging and Therapeutic TrialUniversity Hospital, Bordeaux · NCT01619644
- PHASE4COMPLETEDHuman Fibrinogen Concentrate in Pediatric Cardiac SurgeryNicklaus Children's Hospital f/k/a Miami Children's Hospital · NCT02822599
- NARECRUITINGPhysical Activity and Community EmPOWERment ProjectUniversity of North Carolina, Chapel Hill · NCT06740162
- NAUNKNOWNFunctional Tests to Resolve Unsolved Rare Diseases. Rares.University Hospital, Bordeaux · NCT05696912
- UNKNOWNDiagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants.University Hospital, Bordeaux · NCT04122742
- RECRUITINGOnline Study of People Who Have Genetic Changes and Features of Autism: Simons SearchlightSimons Searchlight · NCT01238250
Wikidata facts
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