EP300
Sign in to saveAlso known as KAT3B, RSTS2, p300, E1A binding protein p300, MKHK2
Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap DNA less tightly. This enzyme plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. The p300 protein appears to
Gene data
EP300- Name
- EP300 lysine acetyltransferase
- Type
- protein-coding
- Position
- 41,091,816–41,180,077 (+)
- Aliases
- KAT3B, MKHK2, RSTS2, p300
- Ensembl
- ENSG00000100393
- RefSeq RNA
- NM_001362843.2, NM_001429.4
- RefSeq protein
- NP_001349772.1, NP_001420.2
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
EP300 lysine acetyltransferase
- Symbol
- EP300
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:41,091,816-41,180,077
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Histone acetyltransferase p300 7ssk.jpeg
Show 5 more facts
- HomoloGene ID
- 1094
- exact match
- identifiers.org/ncbigene/2033
- genomic end
- 41180077
- genomic start
- 41092592
- cytogenetic location
- 22q13.2
Sources (3)
via Wikidata · CC0
~5 min read
Article
7 sectionsContents
- Function
- Mechanism
- Clinical significance
- Interactions
- References
- Further reading
- External links
Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap DNA less tightly. This enzyme plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. The p300 protein appears to be critical for normal development before and after birth.
The EP300 gene is located on the long (q) arm of the human chromosome 22 at position 13.2. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein.