Structure via PubChem · Public domain (PubChem)
diflunisal
Sign in to saveAlso known as 5-(2,4-difluorophenyl)salicylic acid, 2-(hydroxy)-5-(2,4-difluorophenyl)benzoic acid, 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid
Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. It was developed by Merck Sharp & Dohme in 1971, after showing promise in a research project studying more potent chemical analogs of aspirin. It was first sold under the brand name Dolobid, by Merck & Co., but generic versions are widely available. It is classed as a nonsteroidal anti-inflammatory drug (NSAID) and is available in 250 mg and 500 mg tablets.
In the Vinony graph
Vinony's link graph records 507 inbound references to diflunisal, and connects out to salicylic acid, metamizole sodium and Merck & Co..
It is catalogued under topics including Biphenyls, Drugs developed by Merck & Co. and Drugs with non-standard legal status.
Vinony links it to 18 Wikipedia language editions.
Key facts
- Drug.verifiedrevid
- 460785966
- Drug.image
- Diflunisal structure.svg
- Drug.width
- 180
- Drug.image_class
- skin-invert-image
- Drug.image2
- Diflunasil-3D-balls.png
- Drug.width2
- 187
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Dolobid
- Drug.MedlinePlus
- a684037
- Drug.DailyMedID
- Diflunisal
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- N02
- Drug.ATC_suffix
- BA11
- Drug.legal_AU
- S4
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C13H8F2O3
- Molecular weight
- 250.2 g/mol
- IUPAC name
- 5-(2,4-difluorophenyl)-2-hydroxybenzoic acid
- SMILES
- C1=CC(=C(C=C1C2=C(C=C(C=C2)F)F)C(=O)O)O
- InChIKey
- HUPFGZXOMWLGNK-UHFFFAOYSA-N
- XLogP
- 4.4
- Polar surface area
- 57.5 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1982
- Admin. routes
- oral
- Indications
- Fever, pain, rheumatoid arthritis, familial amyloid neuropathy
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 250.044
- Has use
- medication
Show 8 more facts
- World Health Organisation international non-proprietary name
- diflunisal
- chemical formula
- C₁₃H₈F₂O₃
- medical condition treated
- rheumatoid arthritis
- canonical SMILES
- C1=CC(=C(C=C1C2=C(C=C(C=C2)F)F)C(=O)O)O
- defined daily dose
- 0.75
- Commons category
- Diflunisal
- physically interacts with
- Prostaglandin-endoperoxide synthase 1
- legal status (medicine)
- boxed warning
Sources (8)
via Wikidata · CC0
~3 min read
Encyclopedic overview
11 sectionsContents
- Medical uses
- Contraindications
- Amyloidosis
- Side effects
- Mechanism of action
- Duration of effect
- Society and culture
- Legal status
- Research
- References
- Further reading
Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. It was developed by Merck Sharp & Dohme in 1971, after showing promise in a research project studying more potent chemical analogs of aspirin. It was first sold under the brand name Dolobid, by Merck & Co., but generic versions are widely available. It is classed as a nonsteroidal anti-inflammatory drug (NSAID) and is available in 250 mg and 500 mg tablets.
==Medical uses== Diflunisal is indicated for acute or long-term use for symptomatic treatment of mild to moderate pain, osteoarthritis, and rheumatoid arthritis.
Excerpted from Wikipedia’s “diflunisal” article, available under the CC BY-SA 4.0 licence.