RELA

Also known as NFKB3, p65, RELA proto-oncogene, NF-kB subunit, CMCU

Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.

Gene data

RELA

Name: RELA proto-oncogene, NF-kB subunit
Type: protein-coding
Aliases: AIF3BL3, CMCU, NFKB3, p65

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].

via MyGene.info

Gene · Ensembl

RELA proto-oncogene, NF-kB subunit

Symbol: RELA
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:65,653,599-65,663,138
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein RELA PDB 1bft.png

Show 5 more facts

HomoloGene ID: 32064
exact match: identifiers.org/ncbigene/5970
genomic end: 65663090
genomic start: 65653599
cytogenetic location: 11q13.1

Sources (3)

via Wikidata · CC0

~12 min read

Article

17 sections

Contents

Gene and expression
Structure
Phosphorylation
Acetylation
Methylation
Interactions
Role in immune system
Cancer
Prostate
Thyroid
Leukemia
Head and neck
Breast
Monogenic Behçet's Disease-like conditions
References
Further reading
External links

Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.

RELA, also known as p65, is a REL-associated protein involved in NF-κB heterodimer formation, nuclear translocation and activation. NF-κB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc. Phosphorylation and acetylation of RELA are crucial post-translational modifications required for NF-κB activation. RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer.