EIF4G3
Sign in to saveAlso known as eIF-4G 3, eIF4G 3, eIF4GII, eukaryotic translation initiation factor 4 gamma 3
Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene. The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template. Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.
Gene data
EIF4G3- Name
- eukaryotic translation initiation factor 4 gamma 3
- Type
- protein-coding
- Position
- 20,805,989–21,177,285 (−)
- Aliases
- eIF-4G 3, eIF4G 3, eIF4GII
- Ensembl
- ENSG00000075151
- RefSeq RNA
- NM_001198801.3, NM_001198802.3, NM_001198803.2, NM_001391892.1, NM_001391893.1
- RefSeq protein
- NP_001185730.1, NP_001185731.1, NP_001185732.1, NP_001378821.1, NP_001378822.1
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
eukaryotic translation initiation factor 4 gamma 3
- Symbol
- EIF4G3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:20,805,989-21,177,285
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein EIF4G3 PDB 1hu3.png
Show 8 more facts
- HomoloGene ID
- 2789
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8672
- genomic end
- 21177285
- genomic start
- 21132963
- chromosome
- human chromosome 1
- cytogenetic location
- 1p36.12
- expressed in
- middle frontal gyrus
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene. The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template. Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.
== Interactions ==
Excerpted from Wikipedia’s “EIF4G3” article, available under the CC BY-SA 4.0 licence.