CNOT7

Also known as CAF1, Caf1a, hCAF-1, CAF-1, CCR4-NOT transcription complex subunit 7

CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene. It is a subunit of the CCR4-Not deadenylase complex.

Gene data

CNOT7

Name: CCR4-NOT transcription complex subunit 7
Type: protein-coding
Aliases: CAF-1, CAF1, Caf1a, hCAF-1

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016].

via MyGene.info

Gene · Ensembl

CCR4-NOT transcription complex subunit 7

Symbol: CNOT7
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:17,224,966-17,247,726
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein CNOT7 PDB 2d5r.png

Show 5 more facts

HomoloGene ID: 49011
exact match: identifiers.org/ncbigene/29883
genomic end: 17104387
genomic start: 17224966
cytogenetic location: 8p22

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via Wikidata · CC0

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Article

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Contents

Function
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References
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CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene. It is a subunit of the CCR4-Not deadenylase complex.

== Function ==