CNOT1
Sign in to saveAlso known as CDC39, NOT1, NOT1H, AD-005, CCR4-NOT transcription complex subunit 1, HPE12, VIBOS
CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene.
Gene data
CNOT1- Name
- CCR4-NOT transcription complex subunit 1
- Type
- protein-coding
- Position
- 58,518,546–58,629,885 (−)
- Aliases
- AD-005, CDC39, HPE12, NOT1, NOT1H, VIBOS
- Ensembl
- ENSG00000125107
- RefSeq RNA
- NM_001265612.2, NM_016284.5, NM_206999.3, NR_049763.2
- RefSeq protein
- NP_001252541.1, NP_057368.3, NP_996882.1
Enables armadillo repeat domain binding activity; molecular adaptor activity; and nuclear receptor binding activity. Contributes to poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of cytoplasmic mRNA processing body assembly; and regulation of gene expression. Located in P-body and cytosol. Part of CCR4-NOT complex. Implicated in holoprosencephaly. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
CCR4-NOT transcription complex subunit 1
- Symbol
- CNOT1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:58,518,546-58,629,885
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 9453
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23019
- genomic end
- 58629885
- genomic start
- 58553855
- chromosome
- human chromosome 16
- cytogenetic location
- 16q21
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene.
It is a part of the CCR4-Not complex, which deadenylates mRNAs. CNOT1 acts as a scaffold protein, binding other subunits of the complex.
Excerpted from Wikipedia’s “CNOT1” article, available under the CC BY-SA 4.0 licence.