TCEA1

Also known as GTF2S, SII, TCEA, TF2S, TFIIS, transcription elongation factor A1

Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene.

Gene data

TCEA1

Name: transcription elongation factor A1
Type: protein-coding
Position: 53,966,552–54,022,448 (−)
Aliases: GTF2S, SII, TCEA, TF2S, TFIIS
Ensembl: ENSG00000187735
RefSeq RNA: NM_006756.4, NM_201437.3, NR_109901.2, NR_109902.2
RefSeq protein: NP_006747.1, NP_958845.1

Predicted to enable DNA binding activity; translation elongation factor activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within erythrocyte differentiation and positive regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm. Part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

DNA-templated transcription transcription elongation by RNA polymerase II transcription elongation by RNA polymerase II transcription elongation by RNA polymerase II

Molecular function

nucleic acid binding transcription elongation factor activity transcription elongation factor activity protein binding zinc ion binding

Cellular component

nucleus nucleus nucleoplasm nucleoplasm nucleoplasm transcription factor TFIID complex

Pathways

Formation of RNA Pol II elongation complex HIV Life Cycle Late Phase of HIV Life Cycle HIV Infection Disease Formation of HIV elongation complex in the absence of HIV Tat HIV Transcription Elongation Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation

via MyGene.info

Gene · Ensembl

transcription elongation factor A1

Symbol: TCEA1
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:53,966,552-54,022,508
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein TCEA1 PDB 1tfi.png

Show 5 more facts

HomoloGene ID: 55984
exact match: identifiers.org/ncbigene/6917
genomic end: 54022456
genomic start: 54879112
cytogenetic location: 8q11.23

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Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene.

In other organisms, this gene is better known as transcription elongation factor II S (TFIIS). It mainly helps to resolve backtracked elongation complexes by inducing a cut in the RNAP active site, so reaction becomes possible again. It is also found in the eukaryotic transcription preinitiation complex. A homolog in archaea performs the same main task, while bacteria use the non-homologous Gre.