TCEA1

Also known as GTF2S, SII, TCEA, TF2S, TFIIS, transcription elongation factor A1

Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene.

Gene data

TCEA1

Name: transcription elongation factor A1
Type: protein-coding
Position: 53,966,552–54,022,448 (−)
Aliases: GTF2S, SII, TCEA, TF2S, TFIIS
Ensembl: ENSG00000187735
RefSeq RNA: NM_006756.4, NM_201437.3, NR_109901.2, NR_109902.2
RefSeq protein: NP_006747.1, NP_958845.1

Predicted to enable DNA binding activity; translation elongation factor activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within erythrocyte differentiation and positive regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm. Part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

DNA-templated transcription transcription elongation by RNA polymerase II

Article

3 sections

Contents

Interactions
References
Further reading

Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene.

In other organisms, this gene is better known as transcription elongation factor II S (TFIIS). It mainly helps to resolve backtracked elongation complexes by inducing a cut in the RNAP active site, so reaction becomes possible again. It is also found in the eukaryotic transcription preinitiation complex. A homolog in archaea performs the same main task, while bacteria use the non-homologous Gre.