POLR2A

Also known as POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220

DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that is encoded by the POLR2A gene in humans.

Gene data

POLR2A

Name: RNA polymerase II subunit A
Type: protein-coding
Position: 7,484,366–7,514,616 (+)
Aliases: NEDHIB, POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1
Ensembl: ENSG00000181222
RefSeq RNA: NM_000937.5
RefSeq protein: NP_000928.1

This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008].