CDK8

Also known as K35, cyclin-dependent kinase 8, cyclin dependent kinase 8, IDDHBA

protein-coding gene in the species Homo sapiens

Gene data

CDK8

Name: cyclin dependent kinase 8
Type: protein-coding
Aliases: IDDHBA, K35

This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016].

via MyGene.info