TBP

Name

TATA-box binding protein

Type

protein-coding

Position

170,554,302–170,572,870 (+)

Aliases

GTF2D, GTF2D1, HDL4, SCA17, TBP1, TFIID

Ensembl

ENSG00000112592

RefSeq RNA

NM_001172085.2, NM_003194.5

RefSeq protein

NP_001165556.1, NP_003185.1

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016].

via MyGene.info

Gene · Ensembl

TATA-box binding protein

Symbol

TBP

Biotype

Protein coding

Organism

Homo sapiens

Location

6:170,554,266-170,577,194

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein TBP PDB 1c9b.png

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