English
CTD phosphatase subunit 1
Sign in to saveAlso known as CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1, TFIIF-associating CTD phosphatase, TFIIF-associating CTD phosphatase 1, CTD of POLR2A, phosphatase of, subunit 1, RNA polymerase II subunit A C-terminal domain phosphatase, transcription factor IIF-associating CTD phosphatase 1, CTDP1, serine phosphatase FCP1a
RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.
Protein · UniProt
RNA polymerase II subunit A C-terminal domain phosphatase
- Gene
- CTDP1
- Organism
- Homo sapiens (Human)
- Length
- 961 aa
- Molecular mass
- 104,399 Da
- Evidence
- 1: Evidence at protein level
Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
Show 1 more fact
- found in taxon
- Homo sapiens
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- External links
- Further reading
RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.
This gene encodes a protein which interacts with the carboxy-terminus of transcription initiation factor TFIIF, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. The protein may also represent a component of an RNA polymerase II holoenzyme complex. Alternative splicing of this gene results in two transcript variants encoding 2 different isoforms.
Excerpted from Wikipedia’s “CTD phosphatase subunit 1” article, available under the CC BY-SA 4.0 licence.