TOB2

Also known as TOB4, TOBL, TROB2, transducer of ERBB2, 2, APRO5

Protein Tob2 (transducer of ERBB2, 2) is a protein that in humans is encoded by the TOB2 gene.

In the Vinony graph

Within Vinony's link graph, TOB2 is referenced by 3 other articles, and connects out to PubMed, human chromosome 22 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 22.

Its subject is documented across 5 Wikipedia language editions.

Gene data

TOB2

Name: transducer of ERBB2, 2
Type: protein-coding
Position: 41,433,489–41,447,602 (−)
Aliases: APRO5, TOB4, TOBL, TROB2
Ensembl: ENSG00000183864
RefSeq RNA: NM_016272.4, XM_005261315.3, XM_006724105.4, XM_017028539.2, XM_054324992.1
RefSeq protein: NP_057356.1, XP_005261372.1, XP_006724168.1, XP_016884028.1, XP_054180967.1

TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004].

Gene Ontology

Biological process

female gamete generation negative regulation of cell population proliferation negative regulation of cell population proliferation regulation of gene expression negative regulation of DNA-templated transcription

Molecular function

transcription corepressor activity protein binding nuclear vitamin D receptor binding

Cellular component

nucleus nucleus cytoplasm cytoplasm

Pathways

RNA degradation - Homo sapiens (human)Bone morphogenic protein (BMP) signaling and regulation

via MyGene.info

Gene · Ensembl

transducer of ERBB2, 2

Symbol: TOB2
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:41,433,489-41,447,602
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 9447
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/10766
genomic end: 41446801
genomic start: 41433494
chromosome: human chromosome 22
cytogenetic location: 22q13.2

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Interactions
References
Further reading

Protein Tob2 (transducer of ERBB2, 2) is a protein that in humans is encoded by the TOB2 gene.

TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM]

Excerpted from Wikipedia’s “TOB2” article, available under the CC BY-SA 4.0 licence.