CBFA2T2
Sign in to saveAlso known as EHT, MTGR1, ZMYND3, p85, CBFA2/RUNX1 translocation partner 2, CBFA2/RUNX1 partner transcriptional co-repressor 2
Protein CBFA2T2 is a protein that in humans is encoded by the CBFA2T2 gene.
In the Vinony graph
Vinony's link graph records 813 inbound references to CBFA2T2, and connects out to PubMed, human chromosome 20 and homeobox.
Vinony files it under Genes on human chromosome 20 and Transcription factors.
Vinony links it to 5 Wikipedia language editions.
Gene data
CBFA2T2- Name
- CBFA2/RUNX1 partner transcriptional co-repressor 2
- Type
- protein-coding
- Position
- 33,490,060–33,650,036 (+)
- Aliases
- EHT, MTGR1, ZMYND3, p85
- Ensembl
- ENSG00000078699
- RefSeq RNA
- NM_001032999.3, NM_001039709.2, NM_005093.4, NM_175864.1
- RefSeq protein
- NP_001028171.1, NP_001034798.1, NP_005084.1
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
CBFA2/RUNX1 partner transcriptional co-repressor 2
- Symbol
- CBFA2T2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:33,490,060-33,650,036
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 3733
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9139
- genomic end
- 32237842
- genomic start
- 32077881
- chromosome
- human chromosome 20
- cytogenetic location
- 20q11.21-q11.22
- expressed in
- subthalamic nucleus
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Interactions
- References
- Further reading
- External links
Protein CBFA2T2 is a protein that in humans is encoded by the CBFA2T2 gene.
== Function ==
Excerpted from Wikipedia’s “CBFA2T2” article, available under the CC BY-SA 4.0 licence.