CBFA2T3

Name

CBFA2/RUNX1 partner transcriptional co-repressor 3

Type

protein-coding

Position

88,874,858–88,977,207 (−)

Aliases

ETO2, MTG16, MTGR2, RUNX1T3, ZMYND4

Ensembl

ENSG00000129993

RefSeq RNA

NM_005187.6, NM_175931.3, XM_005256323.6, XM_011523419.4, XM_047434826.1

RefSeq protein

NP_005178.4, NP_787127.1, XP_005256380.1, XP_011521721.1, XP_047290782.1

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010].

via MyGene.info

• CBFA2T3-GLIS2-positive acute myeloid leukaemia. A peculiar paediatric entity.British journal of haematology · 2019
• CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax.Cell reports · 2023
• CBFA2T3-GLIS2 mediates transcriptional regulation of developmental pathways through a gene regulatory network.Nature communications · 2024
• CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216.Blood advances · 2024
• CBFA2T3 Is PPARA Sensitive and Attenuates Fasting-Induced Lipid Accumulation in Mouse Liver.Cells · 2024

via PubMed

Wikidata facts

Image

Protein CBFA2T3 PDB 2h7b.png

via Wikidata · CC0