RUNX1T1

Name

RUNX1 partner transcriptional co-repressor 1

Type

protein-coding

Position

91,954,972–92,103,414 (−)

Aliases

AML1-MTG8, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2

Ensembl

ENSG00000079102

RefSeq RNA

NM_001198625.2, NM_001198626.2, NM_001198627.2, NM_001198628.2, NM_001198629.2

RefSeq protein

NP_001185554.1, NP_001185555.1, NP_001185556.1, NP_001185557.1, NP_001185558.1

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010].

via MyGene.info

Gene · Ensembl

RUNX1 partner transcriptional co-repressor 1

Symbol

RUNX1T1

Biotype

Protein coding

Organism

Homo sapiens

Location

8:91,954,972-92,103,414

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein RUNX1T1 PDB 1wq6.png

via Wikidata · CC0