English

English Deutsch Español Français Italiano Nederlands Português Svenska Русский

GeneQ18029703· pop 5· linked from 819 articles

MYBL2

Sign in to save

Also known as B-MYB, BMYB, MYB proto-oncogene like 2

Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.

In the Vinony graph

Within Vinony's link graph, MYBL2 is referenced by 819 other articles, and connects out to PubMed, homeobox and Ensembl genome database project.

Vinony files it under Genes on human chromosome 20 and Transcription factors.

Its subject is documented across 5 Wikipedia language editions.

Gene data

MYBL2

Name: MYB proto-oncogene like 2
Type: protein-coding
Position: 43,667,005–43,716,495 (+)
Aliases: B-MYB, BMYB
Ensembl: ENSG00000101057
RefSeq RNA: NM_001278610.2, NM_002466.4
RefSeq protein: NP_001265539.1, NP_002457.1

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013].

Gene Ontology

Biological process

mitotic cell cycle positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific protein binding sequence-specific double-stranded DNA binding

Cellular component

nucleus nucleus nucleus nucleoplasm nucleoplasm nucleoplasm Myb complex RNA polymerase II transcription regulator complex

Pathways

Cellular senescence - Homo sapiens (human)Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cell Cycle Cell Cycle Generic Transcription Pathway Mitotic G2-G2/M phases Mitotic G1 phase and G1/S transition G2/M Transition

via MyGene.info

Gene · Ensembl

MYB proto-oncogene like 2

Symbol: MYBL2
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:43,667,005-43,716,495
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein MYBL2 PDB 1a5j.png

Show 8 more facts

HomoloGene ID: 1847
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/4605
genomic end: 43716495
genomic start: 42295754
chromosome: human chromosome 20
cytogenetic location: 20q13.12
expressed in: trabecular bone

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections

Contents

Function
Interactions
References
Further reading
External links

Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.

== Function ==

Excerpted from Wikipedia’s “MYBL2” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 20 Transcription factors