CNOT2

Also known as CDC36, NOT2, NOT2H, HSPC131, CCR4-NOT transcription complex subunit 2, IDNADFS

CCR4-NOT transcription complex subunit 2 is a protein that in humans is encoded by the CNOT2 gene. It is a subunit of the CCR4-Not deadenylase complex.

In the Vinony graph

Vinony's link graph records 4 inbound references to CNOT2, and connects out to PubMed, human chromosome 12 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 12.

Vinony links it to 6 Wikipedia language editions.

Gene data

CNOT2

Name: CCR4-NOT transcription complex subunit 2
Type: protein-coding
Position: 70,242,981–70,354,993 (+)
Aliases: CDC36, HSPC131, IDNADFS, NOT2, NOT2H
Ensembl: ENSG00000111596
RefSeq RNA: NM_001199302.2, NM_001199303.2, NM_001414651.1, NM_001414652.1, NM_001414653.1
RefSeq protein: NP_001186231.1, NP_001186232.1, NP_001401580.1, NP_001401581.1, NP_001401582.1

This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010].

Pathways

RNA degradation - Homo sapiens (human)Developmental Biology Generic Transcription Pathway Transcriptional Regulation by TP53 Deadenylation-dependent mRNA decay Deadenylation of mRNA TP53 Regulates Transcription of Cell Cycle Genes TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain RNA Polymerase II Transcription Gene expression (Transcription)

via MyGene.info

Gene · Ensembl

CCR4-NOT transcription complex subunit 2

Symbol: CNOT2
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:70,242,981-70,354,993
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 40953
genetic association: ALS
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/4848
genomic end: 70354993
genomic start: 70243002
chromosome: human chromosome 12
cytogenetic location: 12q15

Sources (5)

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Encyclopedic overview

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References
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Further reading

CCR4-NOT transcription complex subunit 2 is a protein that in humans is encoded by the CNOT2 gene. It is a subunit of the CCR4-Not deadenylase complex.

==References==

Excerpted from Wikipedia’s “CNOT2” article, available under the CC BY-SA 4.0 licence.