XBP1
Sign in to saveAlso known as TREB5, XBP-1, XBP2, TREB-5, X-box binding protein 1
X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. The XBP1 gene is located on chromosome 22 while a closely related pseudogene has been identified and localized to chromosome 5. The XBP1 protein is a transcription factor that regulates the expression of genes important to the proper functioning of the immune system and in the cellular stress response.
Gene data
XBP1- Name
- X-box binding protein 1
- Type
- protein-coding
- Position
- 28,793,534–28,800,597 (−)
- Aliases
- TREB-5, TREB5, XBP-1, XBP2
- Ensembl
- ENSG00000100219
- RefSeq RNA
- NM_001079539.2, NM_001393999.1, NM_001394000.1, NM_005080.4
- RefSeq protein
- NP_001073007.1, NP_001380928.1, NP_001380929.1, NP_005071.2
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
X-box binding protein 1
- Symbol
- XBP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:28,793,534-28,800,597
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~4 min read
Encyclopedic overview
12 sectionsContents
- Discovery
- Function
- MHC class II gene regulation
- Plasma cell differentiation
- Eosinophil differentiation
- Angiogenesis
- Viral replication
- Endoplasmic reticulum stress response
- Clinical significance
- Interactions
- See also
- References
X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. The XBP1 gene is located on chromosome 22 while a closely related pseudogene has been identified and localized to chromosome 5. The XBP1 protein is a transcription factor that regulates the expression of genes important to the proper functioning of the immune system and in the cellular stress response.
== Discovery ==
Excerpted from Wikipedia’s “XBP1” article, available under the CC BY-SA 4.0 licence.