Raf-1 proto-oncogene, serine/threonine kinase
Also known as v-raf-1 murine leukemia viral oncogene-like protein 1, cRaf, C-Raf proto-oncogene, serine/threonine kinase, v-raf-1 murine leukemia viral oncogene homolog 1, raf proto-oncogene serine/threonine protein kinase, proto-oncogene c-RAF, RAF1, Raf-1
RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme that in humans is encoded by the RAF1 gene. The c-Raf protein is part of the ERK1/2 pathway as a MAP kinase (MAP3K) that functions downstream of the Ras subfamily of membrane associated GTPases. C-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases, from the TKL (Tyrosine-kinase-like) group of kinases.
Research
2,144 papers- The Raf-1 serine/threonine protein kinase.Seminars in cancer biology · 1994
- Autoregulation of the Raf-1 serine/threonine kinase.Proceedings of the National Academy of Sciences of the United States of America · 1998
- Signal transduction pathways involving the Raf proto-oncogene.Cancer metastasis reviews · 1994
- Overexpression of the Raf-1 proto-oncogene in human myeloid leukemia.Leukemia research · 1994
- Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.Science (New York, N.Y.) · 2004
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Article
13 sectionsContents
- Discovery
- Structure
- Evolutionary relationships
- Regulation of activity
- Associated human diseases
- Role in cancer
- B-Raf mutations
- As a therapeutic target
- List of interacting proteins
- See also
- References
- Further reading
- External links
RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme that in humans is encoded by the RAF1 gene. The c-Raf protein is part of the ERK1/2 pathway as a MAP kinase (MAP3K) that functions downstream of the Ras subfamily of membrane associated GTPases. C-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases, from the TKL (Tyrosine-kinase-like) group of kinases.
==Discovery==