BRAF

Name

B-Raf proto-oncogene, serine/threonine kinase

Type

protein-coding

Position

140,719,327–140,924,976 (−)

Aliases

B-RAF1, B-raf, BRAF-1, BRAF1, NS7, RAFB1

Ensembl

ENSG00000157764

RefSeq RNA

NM_001354609.2, NM_001374244.1, NM_001374258.1, NM_001378467.1, NM_001378468.1

RefSeq protein

NP_001341538.1, NP_001361173.1, NP_001361187.1, NP_001365396.1, NP_001365397.1

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017].

via MyGene.info

Gene · Ensembl

B-Raf proto-oncogene, serine/threonine kinase

Symbol

BRAF

Biotype

Protein coding

Organism

Homo sapiens

Location

7:140,719,327-140,925,199

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein BRAF PDB 1uwh.png

via Wikidata · CC0