MDK

Also known as ARAP, MK, NEGF2, midkine (neurite growth-promoting factor 2), midkine

Midkine (MK or MDK), also known as neurite growth-promoting factor 2 (NEGF2), is a protein that in humans is encoded by the MDK gene.

Gene data

MDK

Name: midkine
Type: protein-coding
Position: 46,380,756–46,383,837 (+)
Aliases: ARAP, MK, NEGF2
Ensembl: ENSG00000110492
RefSeq RNA: NM_001012333.3, NM_001012334.2, NM_001270550.1, NM_001270551.3, NM_001270552.3
RefSeq protein: NP_001012333.1, NP_001012334.1, NP_001257479.1, NP_001257480.1, NP_001257481.1

This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012].

Gene Ontology

Biological process

behavioral fear response leukocyte chemotaxis involved in inflammatory response leukocyte chemotaxis involved in inflammatory response leukocyte chemotaxis involved in inflammatory response T cell activation involved in immune response T cell activation involved in immune response positive regulation of leukocyte chemotaxis positive regulation of leukocyte chemotaxis

Molecular function

protein binding growth factor activity growth factor activity growth factor activity heparin binding heparin binding chondroitin sulfate binding chondroitin sulfate binding

Cellular component

extracellular region extracellular region extracellular matrix

Pathways

Signaling by NOTCH Signal Transduction Signal Transduction Signaling by NOTCH2 Signaling by ALK Signaling by ALK NOTCH2 Activation and Transmission of Signal to the Nucleus Signaling by Receptor Tyrosine Kinases Signaling by Receptor Tyrosine Kinases MDK and PTN in ALK signaling

via MyGene.info

Gene · Ensembl

midkine

Symbol: MDK
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:46,380,748-46,383,837
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein MDK PDB 1mkc.png

Show 5 more facts

HomoloGene ID: 1792
exact match: identifiers.org/ncbigene/4192
genomic start: 46402306
genomic end: 46405375
cytogenetic location: 11p11.2

Sources (5)

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Contents

Role in cancer
HIV infection
Trivia
References
Further reading
External links

Midkine (MK or MDK), also known as neurite growth-promoting factor 2 (NEGF2), is a protein that in humans is encoded by the MDK gene.

Midkine is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin (NEGF1, 46% homologous with MK). It is a nonglycosylated protein, composed of two domains held by disulfide bridges. It is a developmentally important retinoic acid-responsive gene product strongly induced during mid-gestation, hence the name midkine. Restricted mainly to certain tissues in the normal adult, it is strongly induced during oncogenesis, inflammation and tissue repair.