MERTK

Name

MER proto-oncogene, tyrosine kinase

Type

protein-coding

Position

111,898,607–112,029,561 (+)

Aliases

MER, RP38, Tyro12, c-Eyk, c-mer

Ensembl

ENSG00000153208

RefSeq RNA

NM_006343.3

RefSeq protein

NP_006334.2

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008].