File:Diagram_showing_the_position_of_the_spleen_CRUK_417.svg · Wikimedia Commons · See Wikimedia Commons

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spleen

alt=3D medical animation still showing structure of as well as location of the spleen in human body|thumb|A 3D medical animation still of spleen structure and exact location

AI overview

The spleen is an organ located in the upper left part of your abdomen, beneath the rib cage. It plays important roles in your immune system by filtering blood and helping fight infections, though you can live without it if necessary.

AI-generated from the Wikipedia summary — may contain errors.

Key facts

Anatomy.Name: Spleen
Anatomy.Latin: splen, lien
Anatomy.Greek: σπλήν
Anatomy.Image: Diagram showing the position of the spleen CRUK 417.svg
Anatomy.Caption: Position of the human spleen
Anatomy.System: Immune system (lymphatic system)
Anatomy.Artery: Splenic artery
Anatomy.Vein: Splenic vein
Anatomy.Nerve: Splenic plexus

via Wikipedia infobox

Research

228,574 papers

Targeted spleen modulation: a novel strategy for next-generation disease immunotherapy.ReviewTheranostics · 2025Dong W, Li Y, Fei Q et al.DOI: 10.7150/thno.111116
High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen.eLife · 2024Yang WP, Li MQ, Ding J et al.DOI: 10.7554/eLife.87496
From sadness to stiffness: the spleen's progress.ReviewInternal and emergency medicine · 2019Riva MA, Ferraina F, Paleari A et al.DOI: 10.1007/s11739-019-02115-2
Development of the spleen.ReviewLymphology · 1983Jones JF
Spleen granulopoiesis in psoriasis immune microenvironment aggravates psoriasis via IL-6/P-STAT3 signaling.Biology direct · 2025Shi F, Gong P, Huang S et al.DOI: 10.1186/s13062-025-00675-2
Spleen reactivity during incremental ascent to altitude.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Purdy GM, James MA, Rees JL et al.DOI: 10.1152/japplphysiol.00753.2018
Barrier cells in the spleen.ReviewImmunology today · 1991Weiss LDOI: 10.1016/0167-5699(91)90108-6
Secondary spleen in immune thrombocytopenia: Not so accessory after all….British journal of haematology · 2023Kapur R, Audia SDOI: 10.1111/bjh.18776

via PubMed

Wikidata facts

Image: Spleen.jpg

Show 3 more facts

Commons gallery: Spleen
Commons category: Spleen
NCI Thesaurus ID: C12432

Sources (8)

via Wikidata · CC0

~19 min read

Article

22 sections

Contents

Structure
Measurements
Blood supply
Nerve supply
Development
Function
Pulp
Other
Clinical significance
Enlarged spleen
Splenic injury
Asplenia
Accessory spleen
Infarction
Hyaloserositis
Society and culture
Food
Other animals
Additional images
See also
References
External links

alt=3D medical animation still showing structure of as well as location of the spleen in human body|thumb|A 3D medical animation still of spleen structure and exact location

The spleen (; from Ancient Greek ), or milt, is an organ found in almost all vertebrates. Similar in structure to a large lymph node, it acts primarily as a blood filter.