PRKRA
Sign in to saveAlso known as DYT16, PACT, RAX, HSD14, protein activator of interferon induced protein kinase EIF2AK2
Protein kinase, interferon-inducible double stranded RNA dependent activator, also known as interferon-inducible double stranded RNA-dependent protein kinase activator A or Protein ACTivator of the interferon-induced protein kinase (PACT) is a protein that in humans is encoded by the PRKRA gene. PACT heterodimerizes with and activates protein kinase R. PRKRA mutations have been linked to a rare form of dystonia parkinsonism.
Gene data
PRKRA- Name
- protein activator of interferon induced protein kinase EIF2AK2
- Type
- protein-coding
- Position
- 178,431,292–178,451,512 (−)
- Aliases
- DYT16, HSD14, PACT, RAX
- Ensembl
- ENSG00000180228
- RefSeq RNA
- NM_001139517.2, NM_001139518.2, NM_001316362.2, NM_001446210.1, NM_001446211.1
- RefSeq protein
- NP_001132989.1, NP_001132990.1, NP_001303291.1, NP_001433139.1, NP_001433140.1
This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
protein activator of interferon induced protein kinase EIF2AK2
- Symbol
- PRKRA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:178,431,292-178,451,512
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein PRKRA PDB 2dix.png
Show 5 more facts
- HomoloGene ID
- 2738
- exact match
- identifiers.org/ncbigene/8575
- genomic start
- 178431292
- cytogenetic location
- 2q31.2
- genomic end
- 179316239
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Protein kinase, interferon-inducible double stranded RNA dependent activator, also known as interferon-inducible double stranded RNA-dependent protein kinase activator A or Protein ACTivator of the interferon-induced protein kinase (PACT) is a protein that in humans is encoded by the PRKRA gene. PACT heterodimerizes with and activates protein kinase R. PRKRA mutations have been linked to a rare form of dystonia parkinsonism.
==References==