EIF2AK2

Name

eukaryotic translation initiation factor 2 alpha kinase 2

Type

protein-coding

Position

37,099,210–37,157,688 (−)

Aliases

PKR, PPP1R83, PRKR

Ensembl

ENSG00000055332

RefSeq RNA

NM_001135651.3, NM_001135652.3, NM_002759.4, XM_011532987.3, XM_047445115.1

RefSeq protein

NP_001129123.1, NP_001129124.1, NP_002750.1, XP_011531289.1, XP_047301071.1

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021].