MAP4K4
Sign in to saveAlso known as FLH21957, HEL-S-31, HGK, MEKKK4, NIK, mitogen-activated protein kinase kinase kinase kinase 4
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) – also known as hepatocyte progenitor kinase-like/germinal center kinase-like kinase (HGK) and Nck-interacting kinase (NIK) – is an enzyme, specifically a serine/threonine (S/T) kinase encoded by the MAP4K4 gene in humans.
Gene data
MAP4K4- Name
- mitogen-activated protein kinase kinase kinase kinase 4
- Type
- protein-coding
- Aliases
- FLH21957, HEL-S-31, HGK, MEKKK4, NIK
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
mitogen-activated protein kinase kinase kinase kinase 4
- Symbol
- MAP4K4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:101,696,850-101,894,690
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- 4obo.png
Show 5 more facts
- HomoloGene ID
- 7442
- exact match
- identifiers.org/ncbigene/9448
- genomic end
- 102511149
- genomic start
- 102313312
- cytogenetic location
- 2q11.2
Sources (4)
via Wikidata · CC0
~9 min read
Article
12 sectionsContents
- Discovery and classification
- Structure and expression
- Interactions and signaling
- TNF-α
- p53
- Clinical significance
- Glucose uptake and insulin function
- Atherosclerosis
- Cancer
- References
- Further reading
- External links
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) – also known as hepatocyte progenitor kinase-like/germinal center kinase-like kinase (HGK) and Nck-interacting kinase (NIK) – is an enzyme, specifically a serine/threonine (S/T) kinase encoded by the MAP4K4 gene in humans.
MAP4K4 is involved in a wide array of physiological processes including cell migration, proliferation and adhesion; its activity has been implicated in systemic inflammation, metabolic disorders, cardiovascular disease and cancer.