IRAK4
Sign in to saveAlso known as IPD1, IRAK-4, NY-REN-64, REN64, interleukin 1 receptor associated kinase 4, IMD67
IRAK-4 (interleukin-1 receptor-associated kinase 4), in the IRAK family, is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors. IRAK4 contains domain structures which are similar to those of IRAK1, IRAK2, IRAK3 and Pelle. IRAK4 is unique compared to IRAK1, IRAK2 and IRAKM in that it functions upstream of the other IRAKs, but is more similar to Pelle in this trait. IRAK4 has important clinical applications.
In the Vinony graph
Vinony's link graph records 124 inbound references to IRAK4, and connects out to PubMed, interferon gamma and Ensembl genome database project.
It is catalogued under topics including EC 2.7.11 and Genes on human chromosome 12.
Vinony links it to 4 Wikipedia language editions.
Gene data
IRAK4- Name
- interleukin 1 receptor associated kinase 4
- Type
- protein-coding
- Position
- 43,758,938–43,798,307 (+)
- Aliases
- IMD67, IPD1, IRAK-4, NY-REN-64, REN64
- Ensembl
- ENSG00000198001
- RefSeq RNA
- NM_001114182.3, NM_001145256.2, NM_001145257.2, NM_001145258.2, NM_001351338.2
- RefSeq protein
- NP_001107654.1, NP_001138728.1, NP_001138729.1, NP_001138730.1, NP_001338267.1
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
interleukin 1 receptor associated kinase 4
- Symbol
- IRAK4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:43,758,938-43,798,307
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 41109
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/51135
- genomic end
- 43798307
- genomic start
- 44152747
- chromosome
- human chromosome 12
- cytogenetic location
- 12q12
- expressed in
- appendix
- Commons category
- IRAK4
Sources (6)
via Wikidata · CC0
~10 min read
Encyclopedic overview
11 sectionsContents
- History
- Protein structure
- Function, mechanism, signalling pathway
- Clinical significance
- Prostate cancer
- Melanoma
- Pancreatic cancer
- Drug target
- Inhibitors
- References
- External links
IRAK-4 (interleukin-1 receptor-associated kinase 4), in the IRAK family, is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors. IRAK4 contains domain structures which are similar to those of IRAK1, IRAK2, IRAK3 and Pelle. IRAK4 is unique compared to IRAK1, IRAK2 and IRAKM in that it functions upstream of the other IRAKs, but is more similar to Pelle in this trait. IRAK4 has important clinical applications.
Animals without IRAK-4 are more susceptible to viruses and bacteria but completely resistant to LPS challenge.
Excerpted from Wikipedia’s “IRAK4” article, available under the CC BY-SA 4.0 licence.