TLR1

Also known as CD281, TIL, TIL. LPRS5, rsc786, toll like receptor 1

protein-coding gene in the species Homo sapiens

Gene data

TLR1

Name: toll like receptor 1
Type: protein-coding
Position: 38,787,555–38,856,817 (−)
Aliases: CD281, TIL, TIL. LPRS5, rsc786
Ensembl: ENSG00000174125
RefSeq RNA: NM_003263.4, XM_005262662.6, XM_011513742.4, XM_011513745.4, XM_017008571.3
RefSeq protein: NP_003254.2, XP_005262719.1, XP_011512044.1, XP_011512047.1, XP_016864060.1

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008].