GNAS complex locus
Sign in to saveAlso known as guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Gs alpha subunit, protein SCG6 (secretogranin VI), neuroendocrine secretory protein, guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1, alternative gene product encoded by XL-exon, GNAS, secretogranin VI
mammalian protein found in Homo sapiens
Protein · UniProt
Neuroendocrine secretory protein 55
- Gene
- GNAS
- Organism
- Homo sapiens (Human)
- Length
- 245 aa
- Molecular mass
- 28,029 Da
- Evidence
- 1: Evidence at protein level
Alternative splicingCleavage on pair of basic residuesCushing syndromeCytoplasmic vesicleGlycoproteinProteoglycanProteomics identificationReference proteome
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Research
105 papers- The GNAS complex locus and human diseases associated with loss-of-function mutations or epimutations within this imprinted gene.Hormone research in paediatrics · 2013
- GNAS locus: bone related diseases and mouse models.Frontiers in endocrinology · 2023
- Pseudohypoparathyroidism.Minerva endocrinologica · 2018
- Inactivating GNAS complex locus variants impair G protein-coupled receptor signaling and cause multiple suture craniosynostosis in humans and zebrafish.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
- The Complex GNAS Imprinted Locus and Mesenchymal Stem Cells Differentiation.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2017
via PubMed
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