ATP2B4
Sign in to saveAlso known as ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x, ATPase plasma membrane Ca2+ transporting 4
Plasma membrane calcium-transporting ATPase 4 is an enzyme that in humans is encoded by the ATP2B4 gene.
Gene data
ATP2B4- Name
- ATPase plasma membrane Ca2+ transporting 4
- Type
- protein-coding
- Position
- 203,626,664–203,744,081 (+)
- Aliases
- ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x
- Ensembl
- ENSG00000058668
- RefSeq RNA
- NM_001001396.3, NM_001365783.2, NM_001365784.2, NM_001684.5
- RefSeq protein
- NP_001001396.1, NP_001352712.1, NP_001352713.1, NP_001675.3
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ATPase plasma membrane Ca2+ transporting 4
- Symbol
- ATP2B4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:203,626,664-203,744,081
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- PDB 1cff EBI.jpg
Show 9 more facts
- HomoloGene ID
- 48034
- cytogenetic location
- 1q32.1
- genetic association
- malaria
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/493
- genomic end
- 203713209
- genomic start
- 203626787
- chromosome
- human chromosome 1
- Commons category
- ATP2B4
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Plasma membrane calcium-transporting ATPase 4 is an enzyme that in humans is encoded by the ATP2B4 gene.
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.
Excerpted from Wikipedia’s “ATP2B4” article, available under the CC BY-SA 4.0 licence.