GNG2

Also known as G protein subunit gamma 2

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 is a protein that in humans is encoded by the GNG2 gene.

Gene data

GNG2

Name: G protein subunit gamma 2
Type: protein-coding
Position: 51,826,195–51,979,342 (+)
Aliases: HG3F1
Ensembl: ENSG00000186469
RefSeq RNA: NM_001243773.2, NM_001243774.2, NM_001389707.1, NM_001389708.1, NM_001389709.1
RefSeq protein: NP_001230702.1, NP_001230703.1, NP_001376636.1, NP_001376637.1, NP_001376638.1

This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011].

Gene Ontology

Biological process

G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway cellular response to prostaglandin E stimulus cellular response to catecholamine stimulus

Molecular function

protein binding G-protein beta-subunit binding G-protein beta-subunit binding G-protein beta-subunit binding

Cellular component

heterotrimeric G-protein complex heterotrimeric G-protein complex heterotrimeric G-protein complex heterotrimeric G-protein complex plasma membrane plasma membrane membrane synapse

Pathways

Ras signaling pathway - Homo sapiens (human)Chemokine signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Apelin signaling pathway - Homo sapiens (human)Circadian entrainment - Homo sapiens (human)Retrograde endocannabinoid signaling - Homo sapiens (human)Glutamatergic synapse - Homo sapiens (human)Cholinergic synapse - Homo sapiens (human)Serotonergic synapse - Homo sapiens (human)GABAergic synapse - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

G protein subunit gamma 2

Symbol: GNG2
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:51,826,195-51,979,342
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein GNG2 PDB 1gg2.png

Show 5 more facts

HomoloGene ID: 40715
exact match: identifiers.org/ncbigene/54331
genomic start: 52292913
genomic end: 52446060
cytogenetic location: 14q22.1

Sources (3)

via Wikidata · CC0

~1 min read

Article

3 sections

Contents

Interactive pathway map
References
Further reading

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 is a protein that in humans is encoded by the GNG2 gene.

Heterotrimeric G proteins play vital roles in cellular responses to external signals. The specificity of a G protein-receptor interaction is primarily mediated by the gamma subunit.[supplied by OMIM]